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THG anabolic steroid and receptor

THG anabolic steroid and receptor


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THG anabolic steroid and receptor

THG bound to receptor. Molecular model of a molecule of the anabolic steroid drug tetrahydrogestrinone (THG, ball-and-stick primary structure) bound to a human androgen receptor (secondary structure). THG, also known as The Clear, is the most powerful anabolic steroid synthesised (as of 2008). It binds to both androgen (male sex hormone) and progesterone (female sex hormone) receptors. Binding of THG to androgen receptors causes muscle tissue growth, leading to it being used illegally in competitive sports. Overuse of THG can cause infertility in males and females and suppression of the immune system

Science Photo Library features Science and Medical images including photos and illustrations

Media ID 6275265

© DR MARK J. WINTER/SCIENCE PHOTO LIBRARY

Alpha Helix Anabolic Steroid Androgen Androgen Receptor Androgenic Athletics Ball And Stick Beta Sheet Bound Compound Compounds Doping Drug Helices Illegal Illicit Ligand Molecules Pharmaceutical Pharmaceutics Pharmacological Pharmacology Primary Structure Receptor Secondary Structure Sheets Sport Steroid Steroids Transcription Factor Bio Chemistry Biochemical Molecular Model Protein


EDITORS COMMENTS
This print showcases the intricate molecular structure of THG, a potent anabolic steroid known as The Clear. In this artistic representation, we witness the binding of THG to a human androgen receptor, revealing the complex interplay between this illicit drug and our biological systems. THG is renowned for its ability to bind not only to androgen receptors but also progesterone receptors, making it a formidable force in manipulating hormone signaling pathways. This unique characteristic has led athletes to exploit its muscle tissue growth properties in competitive sports, despite its illegal status. However, the consequences of overusing THG are dire. Both males and females risk infertility due to hormonal imbalances caused by excessive exposure. Additionally, prolonged use can suppress the immune system, posing further health risks. The significance of this image lies not only in its aesthetic appeal but also in shedding light on the biochemical mechanisms behind doping practices prevalent in athletics. By visualizing the interaction between THG and its target receptor at such a detailed level, researchers gain valuable insights into designing effective anti-doping strategies. Science Photo Library's expertly crafted illustration serves as a reminder that while molecules like THG may hold immense power within their structures, they must be handled responsibly within ethical boundaries for both individual well-being and fair competition.

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